• Molecular NameAtracurium
  • SynonymNA
  • Weight929.161
  • Drugbank_IDDB00732
  • ACS_NO64228-79-1
  • Show 2D model
  • LogP (experiment)N/A
  • LogP (predicted, AB/LogP v2.0)-1.33
  • pkaN/A
  • LogD (pH=7, predicted)-1.33
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)-1.99
  • LogSw (predicted, AB/LogsW2.0)8.35
  • Sw (mg/ml) (predicted, ACD/Labs)9.4
  • No.of HBond Donors0
  • No.of HBond Acceptors14
  • No.of Rotatable Bonds26
  • TPSA126.44
  • StatusFDA approved
  • AdministrationIV
  • PharmacologyA neuromuscular-blocking drug or skeletal muscle relaxant in the category of non-depolarizing neuromuscular-blocking drugs, used adjunctively in anesthesia to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation.
  • Absorption_value0.0
  • Absorption (description)N/A
  • Caco_2N/A
  • Bioavailability0.0
  • Protein binding80.0
  • Volume of distribution (VD)0.16 L/kg
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmAfter intravenous administration, it is inactivated in plasma by Hofmann elimination, a non-enzymatic breakdown process occurring at physiological pH and temperature, to produce laudanosine and other metabolites. It also undergoes ester hydrolysis by non-specific plasma esterases. The metabolites have no neuromuscular blocking activity although laudanosine may have some stimulatory action on the CNS.
  • Half life20 min (atracurium); 3 h (laudanosine)
  • ExcretionExcreted in urine and bile, mostly as metabolites. It crosses the placenta.
  • Urinary ExcretionN/A
  • Clerance4.4~6.5 ml/min/kg.
  • ToxicityA 59-day-old infant weighing 2.75 kg received 37 mg of atracurium over 75 min when the syringe driver was set up incorrectly. The infant made a full recovery by 135 min after the infusion was stopped. It was estimated that the plasma-laudanosine concentration at the time neuromuscular function recovered was about 19 mg/L. No atracurium was detectable in the plasma sample taken. [A. J. Charlton et al.,Anaesthesia,1989, 44, 485–486]. A 3-week-old ventilated neonate weighing 3.9 kg received a bolus overdose of atracurium of 5.1 mg/kg in error. Intense bronchospasm occurred, systolic blood pressure fell to 28 mmHg and pulse rate increased from 140/min to 180/min. The neonate recovered within 3 h following treatment with adrenaline and ventilatory support. [J. Durcan and J. A. Carter,Anaesthesia,1986, 41, 767].
  • LD50 (rat)N/A
  • LD50 (mouse)N/A