• Molecular NamePaclitaxel
  • Synonym7-epi-Paclitaxel; 7-epi-Taxol; 7-Epipaclitaxel; 7-Epitaxol; ABI-007
  • Weight853.918
  • Drugbank_IDDB01229
  • ACS_NO33069-62-4
  • Show 3D model
  • LogP (experiment)N/A
  • LogP (predicted, AB/LogP v2.0)3.28
  • pkaN/A
  • LogD (pH=7, predicted)3.28
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)-7.25
  • LogSw (predicted, AB/LogsW2.0)0.0
  • Sw (mg/ml) (predicted, ACD/Labs)0.0
  • No.of HBond Donors4
  • No.of HBond Acceptors15
  • No.of Rotatable Bonds14
  • TPSA221.29
  • StatusFDA approved
  • AdministrationIV
  • PharmacologyA mitotic inhibitor used in cancer chemotherapy.
  • Absorption_valueN/A
  • Absorption (description)N/A
  • Caco_2N/A
  • Bioavailability6.5
  • Protein binding93.0
  • Volume of distribution (VD)2.4 L/kg
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmMetabolized by CYP2C8 and CYP3A, and substrate for P-glycoprotein.
  • Half life3 h (Average accumulation t1/2; longer terminal t?? s up to 30 hours are reported)
  • ExcretionFecal and urinary
  • Urinary Excretion5
  • Clerance5.5 ml/min/kg
  • ToxicityN/A
  • LD50 (rat)N/A
  • LD50 (mouse)N/A