• Molecular NameRifampin
  • SynonymRFP
  • Weight822.953
  • Drugbank_IDDB01045
  • ACS_NO13292-46-1
  • Show 2D model
  • LogP (experiment)4.2
  • LogP (predicted, AB/LogP v2.0)4.69
  • pka1.7, 7.9
  • LogD (pH=7, predicted)1.68
  • Solubility (experiment)3.28 mg/ml
  • LogS (predicted, ACD/Labs)(ph=7)-3.69
  • LogSw (predicted, AB/LogsW2.0)0.36
  • Sw (mg/ml) (predicted, ACD/Labs)0.13
  • No.of HBond Donors6
  • No.of HBond Acceptors16
  • No.of Rotatable Bonds5
  • TPSA220.15
  • StatusFDA approved
  • AdministrationOral, IV
  • PharmacologyA bactericidal antibiotic drug of the rifamycin group.
  • Absorption_value80.0
  • Absorption (description)Complete absorption
  • Caco_2N/A
  • BioavailabilityN/A
  • Protein binding89.0
  • Volume of distribution (VD)0.97 L/kg
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmHepatic and intestinal wall
  • Half life3.5 h
  • Excretion15 to 30% renal, 60% faecal
  • Urinary Excretion7
  • Clerance3.5 ml/min/kg
  • ToxicityChronic exposure may cause nausea and vomiting and unconsciousness
  • LD50 (rat)LD50=1570 mg/kg
  • LD50 (mouse)N/A