• Molecular NameTelithromycin
  • Synonymtelithromycin
  • Weight812.018
  • Drugbank_IDDB00976
  • ACS_NO191114-48-4
  • Show 3D model
  • LogP (experiment)3.731
  • LogP (predicted, AB/LogP v2.0)4.84
  • pkaN/A
  • LogD (pH=7, predicted)3.24
  • Solubility (experiment)0.3 mg/ml
  • LogS (predicted, ACD/Labs)(ph=7)-2.39
  • LogSw (predicted, AB/LogsW2.0)0.14
  • Sw (mg/ml) (predicted, ACD/Labs)0.3
  • No.of HBond Donors1
  • No.of HBond Acceptors15
  • No.of Rotatable Bonds11
  • TPSA171.85
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyThe first ketolide antibiotic to enter clinical use. It is used to treat mild to moderate respiratory infections.
  • Absorption_value90.0
  • Absorption (description)N/A
  • Caco_2N/A
  • Bioavailability57.0
  • Protein binding65.0
  • Volume of distribution (VD)3.0 L/kg
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmApproximately 35% of the dose is metabolized by CYP3A4.
  • Half life12 h
  • ExcretionBiliary and renal
  • Urinary Excretion23
  • Clerance14 ml/min/kg
  • ToxicityN/A
  • LD50 (rat)LD50>2000 mg/kg (PO)
  • LD50 (mouse)N/A