• Molecular NameAcetyldigitoxin
  • SynonymNA
  • Weight806.987
  • Drugbank_IDDB00511
  • ACS_NO1111-393
  • Show 3D model
  • LogP (experiment)3.779
  • LogP (predicted, AB/LogP v2.0)3.01
  • pkaN/A
  • LogD (pH=7, predicted)3.01
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)-4.05
  • LogSw (predicted, AB/LogsW2.0)0.01
  • Sw (mg/ml) (predicted, ACD/Labs)0.07
  • No.of HBond Donors4
  • No.of HBond Acceptors14
  • No.of Rotatable Bonds9
  • TPSA188.9
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyA cardiac glycoside. It is an acetyl derivative of digitoxin.
  • Absorption_valueN/A
  • Absorption (description)65
  • Caco_2N/A
  • Bioavailability70.0
  • Protein binding80.0
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmN/A
  • Half lifePlasma half-life, about 8 to 9 days.
  • ExcretionIt is slowly excreted in the urine, about 20% of a dose being excreted in 6 days; digitoxin accounts for about 60% of the urinary material. About 15 to 20% of a dose is eliminated in the faeces over a period of 18 days.
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityToxicity includes ventricular tachycardia or ventricular fibrillation, or progressive bradyarrhythmias, or heart block. LD50 = 7.8 mg/kg (orally in mice).
  • LD50 (rat)N/A
  • LD50 (mouse)N/A