• Molecular NameThyroxine
  • SynonymNA
  • Weight776.872
  • Drugbank_IDN/A
  • ACS_NO7488-70-2
  • Show 3D model
  • LogP (experiment)N/A
  • LogP (predicted, AB/LogP v2.0)2.54
  • pkaN/A
  • LogD (pH=7, predicted)1.97
  • Solubility (experiment)0.105 mg/ml
  • LogS (predicted, ACD/Labs)(ph=7)-4.71
  • LogSw (predicted, AB/LogsW2.0)0.0
  • Sw (mg/ml) (predicted, ACD/Labs)0.01
  • No.of HBond Donors4
  • No.of HBond Acceptors5
  • No.of Rotatable Bonds5
  • TPSA92.78
  • StatusN/A
  • AdministrationN/A
  • PharmacologyLevothyroxine (T4) is a synthetically prepared levo isomer of thyroxine, the major hormone secreted from the thyroid gland. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form triiodothyronine which exerts a broad spectrum of stimulatory effects on cell metabolism.
  • Absorption_value60.0
  • Absorption (description)N/A
  • Caco_2N/A
  • Bioavailability65.0
  • Protein binding99.95
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmN/A
  • Half lifeN/A
  • ExcretionN/A
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityHypermetabolic state indistinguishable from thyrotoxicosis of endogenous origin. Symptoms of thyrotoxicosis include weight loss, increased appetite, palpitations, nervousness, diarrhea, abdominal cramps, sweating, tachycardia, increased pulse and blood pressure, cardiac arrhythmias, tremors, insomnia, heat intolerance, fever, and menstrual irregularities.
  • LD50 (rat)LD50=20 mg/kg
  • LD50 (mouse)N/A