- Molecular NameDigitoxin
- SynonymDigitalin; Digitoksin; Digitoxinum; Digitoxoside
- Weight764.95
- Drugbank_IDDB01396
- ACS_NO71-63-6
- Show 3D model
- LogP (experiment)2.83
- LogP (predicted, AB/LogP v2.0)2.51
- pkaN/A
- LogD (pH=7, predicted)2.51
- Solubility (experiment)Insoluble
- LogS (predicted, ACD/Labs)(ph=7)-4.04
- LogSw (predicted, AB/LogsW2.0)0.02
- Sw (mg/ml) (predicted, ACD/Labs)0.07
- No.of HBond Donors5
- No.of HBond Acceptors13
- No.of Rotatable Bonds7
- TPSA182.83
- StatusFDA approved
- AdministrationN/A
- PharmacologyA cardiac glycoside.
- Absorption_value90.0
- Absorption (description)Readily absorbed after oral administration.
- Caco_2N/A
- Bioavailability90.0
- Protein binding97.0
- Volume of distribution (VD)0.4 to 0.8 L/kg (mean 0.6); increased in children.
- Blood/Plasma Partitioning ratio (D_blood)Plasma:whole blood ratio, about 1.7.
- MetabollsmExtensively metabolised by hydrolysis to digitoxigenin bisdigitoxoside, digitoxigenin monodigitoxoside, and digitoxigenin, and by hydroxylation to digoxin and the corresponding digoxigenin derivatives, all of which are active. Epimerisation to the inactive metabolites, epidigitoxigenin and epidigoxigenin, followed by glucuronide conjugation also occurs; dihydrodigitoxin has also been detected in plasma.
- Half life5~7 days
- ExcretionAbout 60 to 80% of a single dose is excreted in the urine over a period of 3 weeks, mainly as metabolites, and up to 20% is eliminated in the faeces. The excretion of digitoxin and its active and inactive metabolites is very variable and is independent of dose and route of administration. About 20 to 50% of a dose appears to be excreted as unchanged drug in urine and faeces in variable proportions, and the amount of unchanged drug in the urine has been reported to be greater during maintenance treatment than in single dose studies. Digitoxin is a metabolite of acetyldigitoxin.
- Urinary ExcretionN/A
- Clerance0.04 ml/min/kg; increased in children.
- ToxicityThe estimated minimum lethal dose is 3 mg. Toxic effects are usually associated with serum concentrations of about 0.03 mg/L or more.
- LD50 (rat)N/A
- LD50 (mouse)N/A