- Molecular NameErythromycin
- SynonymEM; Erythrocin; Erythrocin Stearate; Erythromycin estolate; Erythromycin ethylsuccinate; Erythromycin glucoheptonate; Erythromycin lactobionate; Erythromycin oxime; Erythromycin Stearate
- Weight733.937
- Drugbank_IDDB00199
- ACS_NOCAS—114-07-8
- Show 3D model
- LogP (experiment)2.54
- LogP (predicted, AB/LogP v2.0)2.51
- pka8.9
- LogD (pH=7, predicted)0.95
- Solubility (experiment)2 mg/ml
- LogS (predicted, ACD/Labs)(ph=7)-0.34
- LogSw (predicted, AB/LogsW2.0)1.63
- Sw (mg/ml) (predicted, ACD/Labs)26.93
- No.of HBond Donors5
- No.of HBond Acceptors14
- No.of Rotatable Bonds7
- TPSA193.91
- StatusFDA approved
- AdministrationN/A
- PharmacologyA macrolide antibiotic that has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people who have an allergy to penicillins. For respiratory tract infections, it has better coverage of atypical organisms, including mycoplasma and Legionellosis.
- Absorption_value35.0
- Absorption (description)It is also transported by P-glycoprotein, which may contribute to biliary excretion of parent drug and metabolites.
- Caco_2-5.43
- BioavailabilityN/A
- Protein binding84.0
- Volume of distribution (VD)0.78 L/kg
- Blood/Plasma Partitioning ratio (D_blood)Plasma:whole blood ratio, 0.43.
- MetabollsmHepatic. Extensively metabolized - after oral administration, less than 5% of the administered dose can be recovered in the active form in the urine. Erythromycin base is destroyed by gastric acid; erythromycin stearate is hydrolysed in the intestine and absorbed as free erythromycin; the estolate is absorbed as the ester and then hydrolysed.
- Half life1.6 h
- ExcretionAbout 5 to 10% of a dose is excreted in the urine unchanged and large amounts of unchanged drug are excreted in the bile.
- Urinary Excretion12
- Clerance9.1 ml/min/kg
- ToxicitySymptoms of overdose include diarrhea, nausea, stomach cramps, and vomiting.
- LD50 (rat)N/A
- LD50 (mouse)N/A