• Molecular NameDihydroergotoxine
  • SynonymNA
  • Weight679.795
  • Drugbank_IDDB01287
  • ACS_NO8067-24-1
  • Show 3D model
  • LogP (experiment)N/A
  • LogP (predicted, AB/LogP v2.0)-0.95
  • pkaN/A
  • LogD (pH=7, predicted)-1.42
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)-4.69
  • LogSw (predicted, AB/LogsW2.0)961.64
  • Sw (mg/ml) (predicted, ACD/Labs)0.01
  • No.of HBond Donors0
  • No.of HBond Acceptors10
  • No.of Rotatable Bonds7
  • TPSA87.56
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyN/A
  • Absorption_valueN/A
  • Absorption (description)Rapidly but incompletely (approximately 25%) absorbed from the gastrointestinal tract. Approximately 50% of the absorbed dose is eliminated by first-pass metabolism.
  • Caco_2N/A
  • Bioavailability25.0
  • Protein binding98.5
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmHepatic.
  • Half life3.5 h
  • ExcretionN/A
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicitySymptoms of overdose include dyspnea, hypotension or hypertension, rapid weak pulse, delirium, nausea, vomiting, and bradycardia.
  • LD50 (rat)N/A
  • LD50 (mouse)N/A