- Molecular NameLiothyronine
- SynonymL-Liothyronine; Liothyronin; Liothyronine Sodium; T3 liothyronine; Triiodothyronine
- Weight650.976
- Drugbank_IDDB00279
- ACS_NO6893-02-3
- Show 3D model
- LogP (experiment)N/A
- LogP (predicted, AB/LogP v2.0)1.68
- pkaN/A
- LogD (pH=7, predicted)1.66
- Solubility (experiment)0.00396 mg/ml
- LogS (predicted, ACD/Labs)(ph=7)-4.67
- LogSw (predicted, AB/LogsW2.0)0.0
- Sw (mg/ml) (predicted, ACD/Labs)0.01
- No.of HBond Donors4
- No.of HBond Acceptors5
- No.of Rotatable Bonds5
- TPSA92.78
- StatusFDA approved
- AdministrationN/A
- PharmacologyThe L-isomer of triiodothyronine (T3), a form of thyroid hormone used to treat hypothyroidism and myxedema coma.
- Absorption_value95.0
- Absorption (description)Liothyronine is absorbed after oral or IM administration.
- Caco_2N/A
- BioavailabilityN/A
- Protein binding99.7
- Volume of distribution (VD)N/A
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmIt is metabolised by conjugation with glucuronic acid or sulfate, de-iodination oxidative deamination and decarboxylation. It is excreted mainly in the bile and faeces, and is subject to enterohepatic circulation
- Half life2.5 days
- ExcretionSome iodide is excreted in the urine. Endogenous serum concentrations range from 0.0010 to 0.0016 mg/L, in normal subjects.
- Urinary ExcretionN/A
- CleranceN/A
- ToxicityHeadache, irritability, nervousness, sweating, arrhythmia, (including tachycardia), increased bowel motility and menstrual irregularities. Angina pectoris or congestive heart failure may be induced or aggravated. Shock may also develop. Massive overdosage may result in symptoms resembling thyroid storm. Chronic excessive dosage will produce the signs and symptoms of hyperthyroidism. [http://www.rxlist.com/cgi/generic/liothyronine_od.htm#OD]
- LD50 (rat)N/A
- LD50 (mouse)N/A