- Molecular NameAmiodarone
- SynonymAmiodarona [INN-Spanish]; Amiodarone Base; Amiodarone HCL; Amiodarone Hydrochloride; Amiodaronum [INN-Latin]
- Weight645.319
- Drugbank_IDDB01118
- ACS_NO1951-25-3
- Show 3D model
- LogP (experiment)7.706
- LogP (predicted, AB/LogP v2.0)7.41
- pka5.6
- LogD (pH=7, predicted)5.62
- Solubility (experiment)N/A
- LogS (predicted, ACD/Labs)(ph=7)-5.33
- LogSw (predicted, AB/LogsW2.0)0.0
- Sw (mg/ml) (predicted, ACD/Labs)0.0
- No.of HBond Donors0
- No.of HBond Acceptors4
- No.of Rotatable Bonds11
- TPSA42.68
- StatusFDA approved
- AdministrationOral or intravenous
- PharmacologyAn antiarrhythmic agent (medication used for irregular heart beat) used for various types of tachyarrhythmias (fast forms of irregular heart beat), both ventricular and supraventricular (atrial) arrhythmias.
- Absorption_valueN/A
- Absorption (description)Amiodarone is slowly and incompletely absorbed after oral administration; it is distributed to the tissues where it is strongly bound.
- Caco_2N/A
- Bioavailability46.0
- Protein binding99.98
- Volume of distribution (VD)66 L/kg
- Blood/Plasma Partitioning ratio (D_blood)Plasma:whole blood ratio, 1.3.
- MetabollsmLiver. It is metabolised by N-dealkylation to monodesethylamiodarone which is the major plasma metabolite during chronic dosing. High concentrations of amiodarone and monodesethylamiodarone are found in the liver, lungs and adipose tissue.
- Half life25 days
- ExcretionPrimarily Hepatic and Biliary. Only a small amount is excreted in the urine as unchanged drug.
- Urinary Excretion0
- Clerance1.9 ml/min/kg
- ToxicityIntravenous, mouse: LD50 = 178 mg/kg. Some side effects have a significant mortality rate: specifically, hepatitis, exacerbation of asthma and congestive failure, and pneumonitis.
- LD50 (rat)N/A
- LD50 (mouse)N/A