• Molecular NameReserpine
  • SynonymNA
  • Weight608.688
  • Drugbank_IDDB00206
  • ACS_NO50-55-5
  • Show 3D model
  • LogP (experiment)3.72
  • LogP (predicted, AB/LogP v2.0)4.09
  • pka6.6 (25°)
  • LogD (pH=7, predicted)2.12
  • Solubility (experiment)0.073 mg/ml
  • LogS (predicted, ACD/Labs)(ph=7)-4.74
  • LogSw (predicted, AB/LogsW2.0)0.0
  • Sw (mg/ml) (predicted, ACD/Labs)0.01
  • No.of HBond Donors0
  • No.of HBond Acceptors11
  • No.of Rotatable Bonds10
  • TPSA114.35
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyAn indole alkaloid antipsychotic and antihypertensive drug that has been used for the control of high blood pressure and for the relief of psychotic behaviors, although because of the development of better drugs for these purposes and because of its numerous side-effects, it is rarely used today.
  • Absorption_valueN/A
  • Absorption (description)N/A
  • Caco_2N/A
  • Bioavailability50.0
  • Protein binding96.0
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmGut/liver
  • Half lifeextremely variable and may be up to 11 days.
  • Excretion62% feces / 8% urine
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityPossible human carcinogen. May cause reproductive harm. ORL-RAT LD50 420 mg/kg; IPR-RAT LD50 44 mg/kg; IVN-RAT LD50 15 mg/kg; ORL-MUS LD50 200 mg/kg; SCU-MUS LD50 52 mg/kg; IPR-RBT LD50 7 mg/kg
  • LD50 (rat)LD50=420 mg/kg
  • LD50 (mouse)N/A