• Molecular NamePicrotoxin
  • SynonymNA
  • Weight602.589
  • Drugbank_IDDB00466
  • ACS_NO124-87-8
  • Show 3D model
  • LogP (experiment)N/A
  • LogP (predicted, AB/LogP v2.0)-2.43
  • pkaN/A
  • LogD (pH=7, predicted)-2.43
  • Solubility (experiment)4.1 mg/ml
  • LogS (predicted, ACD/Labs)(ph=7)-1.83
  • LogSw (predicted, AB/LogsW2.0)7.99
  • Sw (mg/ml) (predicted, ACD/Labs)4.61
  • No.of HBond Donors0
  • No.of HBond Acceptors7
  • No.of Rotatable Bonds6
  • TPSA92.82
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyA non-competitive antagonist for the GABAA receptor chloride channels. It is therefore a channel blocker rather than a receptor antagonist. As GABA itself is an inhibitory neurotransmitter, infusion of picrotoxin has stimulant and convulsant effects.
  • Absorption_valueN/A
  • Absorption (description)N/A
  • Caco_2N/A
  • BioavailabilityN/A
  • Protein bindingN/A
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmN/A
  • Half lifeN/A
  • ExcretionN/A
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityIn large doses it is a powerful poison, causing unconsciousness, delirium, convulsions, gastro-enteritis and stimulation of the respiratory centre followed by paralysis, from which death sometimes results.
  • LD50 (rat)N/A
  • LD50 (mouse)LD50=15 mg/kg