• Molecular NameAntrafenine
  • SynonymNA
  • Weight588.552
  • Drugbank_IDDB01419
  • ACS_NO55300-30-6
  • Show 2D model
  • LogP (experiment)0.82
  • LogP (predicted, AB/LogP v2.0)6.86
  • pka7.72; 10.04
  • LogD (pH=7, predicted)6.71
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)-7.26
  • LogSw (predicted, AB/LogsW2.0)0.0
  • Sw (mg/ml) (predicted, ACD/Labs)0.0
  • No.of HBond Donors1
  • No.of HBond Acceptors6
  • No.of Rotatable Bonds10
  • TPSA57.7
  • StatusEU withdrawn, FDA approved
  • AdministrationN/A
  • PharmacologyA piperazine derivative drug invented in 1979. It acts as an analgesic and anti-inflammatory drug with similar efficacy to naproxen, but is not widely used as it has largely been replaced by newer drugs.
  • Absorption_valueN/A
  • Absorption (description)N/A
  • Caco_2N/A
  • Bioavailability100.0
  • Protein binding97.5
  • Volume of distribution (VD)0.75 L/kg
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • Metabollsmhepatic
  • Half life2.8 h (intravenous administration) or 5.7 h (oral)
  • Excretionrenal
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityN/A
  • LD50 (rat)N/A
  • LD50 (mouse)N/A