- Molecular NameBethanechol
- SynonymAmidopropyldimethylbetaine; Besacholine; Beta-Methyl Carbachol Chloride; Bethaine Choline Chloride; Bethanechol Chloride; BTC; Carbamylmethylcholine Chloride
- Weight161.225
- Drugbank_IDDB01019
- ACS_NO674-38-4
- Show 2D model
- LogP (experiment)-3.4
- LogP (predicted, AB/LogP v2.0)-3.92
- pkaN/A
- LogD (pH=7, predicted)-3.92
- Solubility (experiment)10 mg/ml (chloride salt)
- LogS (predicted, ACD/Labs)(ph=7)0.39
- LogSw (predicted, AB/LogsW2.0)2084.79
- Sw (mg/ml) (predicted, ACD/Labs)399.03
- No.of HBond Donors2
- No.of HBond Acceptors4
- No.of Rotatable Bonds4
- TPSA52.32
- StatusFDA approved
- AdministrationOral, subcutaneous
- PharmacologyA parasympathomimetic choline ester that selectively stimulates muscarinic receptors (with further selectivity for M3 receptors) without any effect on nicotinic receptors.
- Absorption_valueN/A
- Absorption (description)N/A
- Caco_2N/A
- BioavailabilityN/A
- Protein bindingN/A
- Volume of distribution (VD)N/A
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmN/A
- Half lifeN/A
- ExcretionN/A
- Urinary ExcretionN/A
- CleranceN/A
- ToxicityAdverse reactions are rare following oral administration of bethanechol, but are more common following subcutaneous injection. The following side effects have been observed: malaise; abdominal cramps or discomfort, colicky pain, nausea and belching, diarrhea, borborygmi, salivation; urinary urgency; headache; a fall in blood pressure with reflex tachycardia, vasomotor response; flushing producing a feeling of warmth, sensation of heat about the face, sweating; bronchial constriction, asthmatic attacks; lacrimation, miosis.
- LD50 (rat)N/A
- LD50 (mouse)N/A