• Molecular NameCeftriaxone
  • SynonymCefatriaxone; Ceftriaxona [INN-Spanish]; Ceftriaxonum [INN-Latin]; Ceftriazone
  • Weight554.589
  • Drugbank_IDDB01212
  • ACS_NO73384-59-5
  • Show 3D model
  • LogP (experiment)-1.341
  • LogP (predicted, AB/LogP v2.0)-0.96
  • pka3, 3.2, 4.1
  • LogD (pH=7, predicted)-5.95
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)-0.12
  • LogSw (predicted, AB/LogsW2.0)0.05
  • Sw (mg/ml) (predicted, ACD/Labs)0.11
  • No.of HBond Donors5
  • No.of HBond Acceptors15
  • No.of Rotatable Bonds8
  • TPSA291.31
  • StatusFDA approved
  • AdministrationIntravenous, intramuscular
  • PharmacologyA third-generation cephalosporin antibiotic.
  • Absorption_value1.0
  • Absorption (description)N/A
  • Caco_2-6.88
  • Bioavailability0.0
  • Protein binding92.5
  • Volume of distribution (VD)5.8~13.5 L
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmNegligible
  • Half life6~9 h
  • ExcretionHigh concentrations are found in bile. About 40 to 65% of a dose is excreted unchanged in urine, mainly by glomerular filtration; the remainder is excreted in bile and is found in faeces as the unchanged drug and inactive metabolites.
  • Urinary ExcretionN/A
  • Clerance0.58~1.45 L/h
  • ToxicityN/A
  • LD50 (rat)N/A
  • LD50 (mouse)N/A