• Molecular NameCiclesonide
  • Synonymciclesonide
  • Weight540.697
  • Drugbank_IDDB01410
  • ACS_NO141845-82-1
  • Show 3D model
  • LogP (experiment)N/A
  • LogP (predicted, AB/LogP v2.0)4.85
  • pkaN/A
  • LogD (pH=7, predicted)4.85
  • Solubility (experiment)Insoluble
  • LogS (predicted, ACD/Labs)(ph=7)-6.29
  • LogSw (predicted, AB/LogsW2.0)0.01
  • Sw (mg/ml) (predicted, ACD/Labs)0.0
  • No.of HBond Donors1
  • No.of HBond Acceptors7
  • No.of Rotatable Bonds6
  • TPSA99.13
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyA glucocorticoid used to treat obstructive airway diseases.
  • Absorption_valueN/A
  • Absorption (description)N/A
  • Caco_2N/A
  • Bioavailability1.0
  • Protein binding99.0
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmIntranasal ciclesonide is hydrolyzed to a biologically active metabolite, des-ciclesonide, by esterases in the nasal mucosa. Des-ciclesonide undergoes further metabolism in the liver to additional metabolites mainly by the cytochrome P450 (CYP) 3A4 isozyme and to a lesser extent by CYP 2D6. The full range of potentially active metabolites of ciclesonide has not been characterized. After intravenous administration of 14C-ciclesonide, 19.3% of the resulting radioactivity in the plasma is accounted for by ciclesonide or des-ciclesonide; the remainder may be a result of other, as yet, unidentified multiple metabolites.
  • Half lifeFollowing intravenous administration of 800 mcg of ciclesonide, the clearance values of ciclesonide and des-ciclesonide were high (approximately 152 L/h and 228 L/h, respectively). 14C-labeled ciclesonide was predominantly excreted via the feces after intravenous administration (66%) indicating that excretion through bile is the major route of elimination. Approximately 20% or less of drug related radioactivity was excreted in the urine.
  • ExcretionN/A
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityAdverse effects in patient with seasonal and perrenial allergic rhinitis include headache, epistaxis, nasopharyngitis, ear pain.
  • LD50 (rat)N/A
  • LD50 (mouse)N/A