• Molecular NameMezlocillin
  • SynonymNA
  • Weight539.59
  • Drugbank_IDDB00948
  • ACS_NO51481-65-3
  • Show 3D model
  • LogP (experiment)N/A
  • LogP (predicted, AB/LogP v2.0)0.84
  • pkaN/A
  • LogD (pH=7, predicted)-3.13
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)0.08
  • LogSw (predicted, AB/LogsW2.0)2.15
  • Sw (mg/ml) (predicted, ACD/Labs)0.65
  • No.of HBond Donors3
  • No.of HBond Acceptors13
  • No.of Rotatable Bonds6
  • TPSA207.18
  • StatusFDA approved; US withdrawn
  • AdministrationIntravenous, intramuscular
  • PharmacologyA broad-spectrum penicillin antibiotic. It is active against both Gram-negative and some Gram-positive bacteria.
  • Absorption_value0.0
  • Absorption (description)N/A
  • Caco_2N/A
  • BioavailabilityN/A
  • Protein binding37.5
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmUnlike many other penicillins, mezlocillin is either extensively metabolized or is subject to biliary excretion, as only about 50% of the dose was accounted for in normal urine.
  • Half life1.3~4.4 h
  • ExcretionRenal (50%) and biliary
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicitySymptoms of overdose include rash, fever, chills, and peeling skin.
  • LD50 (rat)N/A
  • LD50 (mouse)N/A