• Molecular NameRocuronium
  • SynonymNA
  • Weight529.786
  • Drugbank_IDDB00728
  • ACS_NO119302-91-9
  • Show 3D model
  • LogP (experiment)N/A
  • LogP (predicted, AB/LogP v2.0)-0.55
  • pkaN/A
  • LogD (pH=7, predicted)-0.66
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)-0.54
  • LogSw (predicted, AB/LogsW2.0)48.35
  • Sw (mg/ml) (predicted, ACD/Labs)68.99
  • No.of HBond Donors1
  • No.of HBond Acceptors6
  • No.of Rotatable Bonds6
  • TPSA59.0
  • StatusFDA approved
  • AdministrationIntravenous
  • PharmacologyAn aminosteroid non-depolarizing (that is, it does not cause initial stimulation of muscles before weakening them) neuromuscular blocker or muscle relaxant used in modern anaesthesia, to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation.
  • Absorption_valueN/A
  • Absorption (description)N/A
  • Caco_2N/A
  • BioavailabilityN/A
  • Protein binding30.0
  • Volume of distribution (VD)0.19~0.31 L/kg
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmSome de-acetylation
  • Half life1.2~2.2 h
  • ExcretionUnchanged, in bile and urine
  • Urinary Excretion12~22
  • Clerance3.3~5.2 ml/min/kg
  • ToxicityNo cases of significant accidental or intentional overdose have been reported. Overdosage with neuromuscular blocking agents may result in neuromuscular block beyond the time needed for surgery and anesthesia.
  • LD50 (rat)N/A
  • LD50 (mouse)N/A