- Molecular NameChlorhexidine
- SynonymChlorhexidin [Czech]; Chlorhexidine Base; Chlorhexidine Gluconate; Chlorhexidinum [INN-Latin]; Cloresidina [DCIT]; Clorhexidina [INN-Spanish]; Decanoylacetaldehyde Sodium Sulfide
- Weight505.458
- Drugbank_IDDB00878
- ACS_NO55-56-1
- Show 3D model
- LogP (experiment)4.066
- LogP (predicted, AB/LogP v2.0)2.59
- pka10.8
- LogD (pH=7, predicted)-2.4
- Solubility (experiment)N/A
- LogS (predicted, ACD/Labs)(ph=7)-3.23
- LogSw (predicted, AB/LogsW2.0)0.0
- Sw (mg/ml) (predicted, ACD/Labs)0.24
- No.of HBond Donors10
- No.of HBond Acceptors10
- No.of Rotatable Bonds13
- TPSA177.58
- StatusFDA approved
- AdministrationN/A
- PharmacologyA chemical antiseptic.
- Absorption_valueN/A
- Absorption (description)Absorption of chlorhexidine from the gastrointestinal tract is very poor. Additionally, an in vivo study in 18 adult patients found no detectable plasma or urine chlorhexidine concentrations following insertion of four periodontal implants under clinical conditions.
- Caco_2N/A
- Bioavailability1.0
- Protein binding87.0
- Volume of distribution (VD)N/A
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmN/A
- Half lifeN/A
- ExcretionN/A
- Urinary ExcretionN/A
- CleranceN/A
- ToxicityLD50= 2g/kg (human, oral); A 58-year-old Japanese woman suffering from articular rheumatism underwent synovectomy on her finger. While in hospital she received an injection of antibiotics. 20 min later she went into cardiac arrest and after 100 min she died. A concentration of chlorhexidine was detected in the serum taken from the right side of her heart at a level of 39.5 mg/L only 27 h after death. [K. Kudo et al.,J. Anal. Toxicol.,2002, 26(2), 119–122.]
- LD50 (rat)LD50= 3 g/kg (rat, oral);LD50= 21 mg/kg (male rat, IV); LD50= 23 mg/kg (female rat, IV); LD 50= 1g/kg (rat, subcutaneous);
- LD50 (mouse)LD50= 2.5 g/kg (mice, oral); LD50= 25 mg/kg (male mice, IV); LD50= 24 mg/kg (female mice, IV); LD50= 632 mg/kg (female mice, subcutaneous)