- Molecular NameDipyridamole
- SynonymDipiridamol; Dipyridamine; Dipyridamol; Dipyudamine; Dypyridamol; Usaf Ge-12
- Weight504.636
- Drugbank_IDDB00975
- ACS_NO58-32-2
- Show 3D model
- LogP (experiment)N/A
- LogP (predicted, AB/LogP v2.0)1.83
- pka6.4
- LogD (pH=7, predicted)1.72
- Solubility (experiment)N/A
- LogS (predicted, ACD/Labs)(ph=7)-2.64
- LogSw (predicted, AB/LogsW2.0)0.11
- Sw (mg/ml) (predicted, ACD/Labs)0.9
- No.of HBond Donors4
- No.of HBond Acceptors12
- No.of Rotatable Bonds12
- TPSA145.44
- StatusFDA approved
- AdministrationPO, IV
- PharmacologyA drug that inhibits thrombus formation when given chronically and causes vasodilation when given at high doses over short time.
- Absorption_value58.0
- Absorption (description)Readily absorbed after oral administration.
- Caco_2N/A
- Bioavailability50.0
- Protein binding90.0
- Volume of distribution (VD)2.5 L/kg
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmHepatic
- Half life40 min
- ExcretionEliminated mainly in the faeces; excretion may be delayed due to enterohepatic circulation. Small amounts are excreted in the urine as the glucuronide conjugate.
- Urinary ExcretionN/A
- Clerance2 ml/min/kg
- ToxicityHypotension, if it occurs, is likely to be of short duration, but a vasopressor drug may be used if necessary.
- LD50 (rat)LD50=8.4g/kg
- LD50 (mouse)N/A