• Molecular NameAmcinonide
  • SynonymNA
  • Weight502.579
  • Drugbank_IDDB00288
  • ACS_NO51022-69-6
  • Show 3D model
  • LogP (experiment)3.269
  • LogP (predicted, AB/LogP v2.0)2.97
  • pkaN/A
  • LogD (pH=7, predicted)2.97
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)-4.59
  • LogSw (predicted, AB/LogsW2.0)0.09
  • Sw (mg/ml) (predicted, ACD/Labs)0.01
  • No.of HBond Donors1
  • No.of HBond Acceptors7
  • No.of Rotatable Bonds4
  • TPSA99.13
  • StatusFDA approved
  • AdministrationTopical
  • PharmacologyA corticosteroid.
  • Absorption_valueN/A
  • Absorption (description)Topical corticosteroids can be absorbed from normal intact skin. Inflammation and/or other disease processes in the skin increase percutaneous absorption.
  • Caco_2N/A
  • BioavailabilityN/A
  • Protein bindingN/A
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmOnce absorbed through the skin, topical corticosteroids are handled through pharmacokinetic pathways similar to systemically administered corticosteroids. Corticosteroids are metabolized primarily in the liver and are then excreted by the kidneys.
  • Half lifeN/A
  • ExcretionN/A
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityResults from acute toxicity studies do not indicate that any risk of acute intoxication is to be expected following a single dermal application of an overdose (application over a large area under conditions favorable to absorption) or inadvertent oral ingestion.
  • LD50 (rat)N/A
  • LD50 (mouse)N/A