• Molecular NameClocortolone
  • SynonymClocortolone pivalate
  • Weight495.031
  • Drugbank_IDDB00838
  • ACS_NO34097-16-0
  • Show 3D model
  • LogP (experiment)N/A
  • LogP (predicted, AB/LogP v2.0)4.29
  • pkaN/A
  • LogD (pH=7, predicted)4.29
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)-6.0
  • LogSw (predicted, AB/LogsW2.0)0.0
  • Sw (mg/ml) (predicted, ACD/Labs)0.0
  • No.of HBond Donors1
  • No.of HBond Acceptors5
  • No.of Rotatable Bonds5
  • TPSA80.67
  • StatusFDA approved
  • AdministrationTopical
  • PharmacologyA corticosteroid.
  • Absorption_valueN/A
  • Absorption (description)Topical corticosteroids can be absorbed from intact healthy skin. The extent of percutaneous absorption of topical corticosteroids is determined by many factors, including the vehicle and the integrity of the epidermal barrier. Occlusion, inflammation and/or other disease processes in the skin may also increase percutaneous absorption.
  • Caco_2N/A
  • BioavailabilityN/A
  • Protein bindingN/A
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmMetabolized, primarily in the liver, and then excreted by the kidneys.
  • Half lifeN/A
  • ExcretionN/A
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityTopically applied clocortolone can be absorbed in sufficient amounts to produce systemic effects. Symptoms of overdose include thinning of skin and suppression of adrenal cortex (decreased ability to respond to stress).
  • LD50 (rat)N/A
  • LD50 (mouse)N/A