• Molecular NameNicardipine
  • SynonymNicardipine HCl; Nicardipino [INN-Spanish]; Nicardipinum [INN-Latin]
  • Weight493.56
  • Drugbank_IDDB00622
  • ACS_NO55985-32-5
  • Show 3D model
  • LogP (experiment)4.65
  • LogP (predicted, AB/LogP v2.0)4.96
  • pka7.24
  • LogD (pH=7, predicted)1.88
  • Solubility (experiment)0.0022 mg/ml
  • LogS (predicted, ACD/Labs)(ph=7)-4.95
  • LogSw (predicted, AB/LogsW2.0)0.0
  • Sw (mg/ml) (predicted, ACD/Labs)0.0
  • No.of HBond Donors1
  • No.of HBond Acceptors9
  • No.of Rotatable Bonds11
  • TPSA116.7
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyNicardipine, a dihydropyridine calcium-channel blocker, is used alone or with an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris, and Prinzmetal's variant angina.
  • Absorption_value95.0
  • Absorption (description)N/A
  • Caco_2N/A
  • Bioavailability23.0
  • Protein binding95.0
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmNicardipine HCl is metabolized extensively by the liver.
  • Half life8.6 h
  • ExcretionN/A
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityN/A
  • LD50 (rat)LD50=184 mg/kg
  • LD50 (mouse)LD50=322 mg/kg