• Molecular NameRosuvastatin
  • SynonymRosuvastatin calcium; ZD-4522
  • Weight481.545
  • Drugbank_IDDB01098
  • ACS_NO287714-41-4
  • Show 3D model
  • LogP (experiment)N/A
  • LogP (predicted, AB/LogP v2.0)1.89
  • pkaN/A
  • LogD (pH=7, predicted)-0.76
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)-0.37
  • LogSw (predicted, AB/LogsW2.0)0.05
  • Sw (mg/ml) (predicted, ACD/Labs)0.43
  • No.of HBond Donors3
  • No.of HBond Acceptors9
  • No.of Rotatable Bonds10
  • TPSA149.3
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyA member of the drug class of statins, used to treat high cholesterol and related conditions, and to prevent cardiovascular disease.
  • Absorption_valueN/A
  • Absorption (description)N/A
  • Caco_2N/A
  • Bioavailability20.0
  • Protein binding88.0
  • Volume of distribution (VD)1.8 L/kg
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmLiver
  • Half life20 h
  • ExcretionEliminated primarily by biliary excretion; also appears to be actively transported into the liver by an organic anion transport protein (OATP2/SLC21A6).
  • Urinary Excretion30
  • Clerance10.5 ml/min/kg
  • ToxicityN/A
  • LD50 (rat)N/A
  • LD50 (mouse)N/A