- Molecular NameGentamicin_C1
- SynonymNA
- Weight477.603
- Drugbank_IDDB00798
- ACS_NO1403-66-3
- Show 3D model
- LogP (experiment)N/A
- LogP (predicted, AB/LogP v2.0)-4.76
- pkaN/A
- LogD (pH=7, predicted)-9.6
- Solubility (experiment)N/A
- LogS (predicted, ACD/Labs)(ph=7)0.32
- LogSw (predicted, AB/LogsW2.0)275.22
- Sw (mg/ml) (predicted, ACD/Labs)1000.0
- No.of HBond Donors11
- No.of HBond Acceptors12
- No.of Rotatable Bonds7
- TPSA199.73
- StatusFDA approved
- AdministrationN/A
- PharmacologyAn aminoglycoside antibiotic, used to treat many types of bacterial infections, particularly those caused by Gram-negative bacteria.
- Absorption_value0.0
- Absorption (description)Poorly absorbed after oral administration but rapidly absorbed after IM injection; it is also absorbed systemically following topical application to wounds.
- Caco_2N/A
- Bioavailability0.0
- Protein binding10.0
- Volume of distribution (VD)0.31 L/kg
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmN/A
- Half life2~3 h
- ExcretionIn normal subjects it is rapidly excreted in the urine as unchanged drug, up to 80% of a dose being excreted in 24 h. It accumulates in the tissues and there may be considerable intersubject variation in the pharmacokinetics. Gentamicin may be detected in serum and urine for several days after cessation of treatment.
- Urinary Excretion>90
- Clerance1 mL/min/kg
- ToxicityToxic effects may be produced at serum concentrations of 12 mg/L or more, or during chronic treatment, if the trough serum concentration exceeds 2 mg/L.
- LD50 (rat)N/A
- LD50 (mouse)N/A