• Molecular NameLoperamide
  • SynonymNA
  • Weight477.048
  • Drugbank_IDDB00836
  • ACS_NO53179-11-6
  • Show 3D model
  • LogP (experiment)N/A
  • LogP (predicted, AB/LogP v2.0)5.62
  • pka8.6
  • LogD (pH=7, predicted)4.21
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)-3.11
  • LogSw (predicted, AB/LogsW2.0)0.01
  • Sw (mg/ml) (predicted, ACD/Labs)0.06
  • No.of HBond Donors1
  • No.of HBond Acceptors4
  • No.of Rotatable Bonds7
  • TPSA43.78
  • StatusFDA approved
  • Administrationoral, insufflation
  • PharmacologyA drug effective against diarrhea resulting from gastroenteritis or inflammatory bowel disease.
  • Absorption_valueN/A
  • Absorption (description)Loperamide is poorly absorbed after oral administration.
  • Caco_2N/A
  • Bioavailability40.0
  • Protein binding97.0
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmHepatic
  • Half life11 h
  • ExcretionAbout 1 to 2% of a dose is excreted in the urine as free or conjugated loperamide in 48 h. Up to 10% of a dose may be excreted in the urine in 8 days and about 40% is eliminated in the faeces over the same period.
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicitySymptoms of overdose include constipation, drowsiness, lethargy, and nausea.
  • LD50 (rat)LD50=185 (po)
  • LD50 (mouse)LD50=105 mg/kg