• Molecular NameHydrocortamate
  • SynonymNA
  • Weight475.626
  • Drugbank_IDDB00769
  • ACS_NO76-47-1
  • Show 3D model
  • LogP (experiment)2.953
  • LogP (predicted, AB/LogP v2.0)2.68
  • pkaN/A
  • LogD (pH=7, predicted)2.09
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)-4.14
  • LogSw (predicted, AB/LogsW2.0)0.06
  • Sw (mg/ml) (predicted, ACD/Labs)0.0
  • No.of HBond Donors2
  • No.of HBond Acceptors7
  • No.of Rotatable Bonds8
  • TPSA104.14
  • StatusFDA approved
  • Administrationointment; topical (0.5%)
  • PharmacologyHydrocortamate is a synthetic glucocorticoid used for its anti-inflammatory or immunosuppressive properties to treat inflammation due to corticosteroid-responsive dermatoses.
  • Absorption_valueN/A
  • Absorption (description)N/A
  • Caco_2N/A
  • BioavailabilityN/A
  • Protein bindingN/A
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmPrimarily hepatic via CYP3A4
  • Half lifeN/A
  • ExcretionN/A
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicitySide effects include burning, itching, irritation, dryness, folliculitis, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, maceration of the skin, secondary infection, skin atrophy, striae, miliaria.
  • LD50 (rat)N/A
  • LD50 (mouse)N/A