• Molecular NameSildenafil
  • SynonymSildenafil Citrate
  • Weight474.586
  • Drugbank_IDDB00203
  • ACS_NO139755-83-2
  • Show 2D model
  • LogP (experiment)N/A
  • LogP (predicted, AB/LogP v2.0)0.73
  • pkaN/A
  • LogD (pH=7, predicted)0.43
  • Solubility (experiment)3.5 mg/ml
  • LogS (predicted, ACD/Labs)(ph=7)-4.81
  • LogSw (predicted, AB/LogsW2.0)0.24
  • Sw (mg/ml) (predicted, ACD/Labs)0.01
  • No.of HBond Donors1
  • No.of HBond Acceptors10
  • No.of Rotatable Bonds7
  • TPSA117.51
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyA drug used to treat erectile dysfunction and pulmonary arterial hypertension (PAH).
  • Absorption_valueN/A
  • Absorption (description)N/A
  • Caco_2N/A
  • Bioavailability38.0
  • Protein binding96.0
  • Volume of distribution (VD)1.2 L/kg
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmHepatic (mostly CYP3A4, also CYP2C9)
  • Half life2.4 h
  • ExcretionFecal (80%) and renal (around 13%)
  • Urinary Excretion0
  • Clerance6.0 ml/min/kg
  • ToxicitySide effects reported in clinical trials include: headache, dyspepsia, nasal congestion, urinary tract infection, abnormal vision, diarrhea, dizziness, rash
  • LD50 (rat)N/A
  • LD50 (mouse)N/A