- Molecular NameFolinic acid
- SynonymCalcium folinate; Leucovorin; Folinic acid calcium salt; Folinic acid calcium salt USP27; L-leucovorin; Leucovorin calcium; Leucovorin folinic acid
- Weight473.446
- Drugbank_IDDB00650
- ACS_NO1492-18-8
- Show 3D model
- LogP (experiment)N/A
- LogP (predicted, AB/LogP v2.0)-2.8
- pkaN/A
- LogD (pH=7, predicted)-7.69
- Solubility (experiment)Slightly soluble
- LogS (predicted, ACD/Labs)(ph=7)0.32
- LogSw (predicted, AB/LogsW2.0)0.14
- Sw (mg/ml) (predicted, ACD/Labs)58.17
- No.of HBond Donors8
- No.of HBond Acceptors14
- No.of Rotatable Bonds9
- TPSA215.55
- StatusFDA approved
- AdministrationIntravenous, oral
- PharmacologyAn adjuvant used in cancer chemotherapy involving the drug methotrexate.
- Absorption_value90.0
- Absorption (description)Following oral administration, leucovorin is rapidly absorbed. The apparent bioavailability of leucovorin was 97% for 25 mg, 75% for 50 mg, and 37% for 100 mg.
- Caco_2N/A
- BioavailabilityN/A
- Protein binding15.0
- Volume of distribution (VD)N/A
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmN/A
- Half life6.2 h
- ExcretionUrinary
- Urinary ExcretionN/A
- CleranceN/A
- ToxicityExcessive amounts of leucovorin may nullify the chemotherapeutic effect of folic acid antagonists.
- LD50 (rat)LD50>8000 mg/kg
- LD50 (mouse)N/A