• Molecular NameTerfenadine
  • SynonymTernadin
  • Weight471.685
  • Drugbank_IDDB00342
  • ACS_NO50679-08-8
  • Show 2D model
  • LogP (experiment)5.69
  • LogP (predicted, AB/LogP v2.0)5.64
  • pkaN/A
  • LogD (pH=7, predicted)3.1
  • Solubility (experiment)0.00999 mg/ml
  • LogS (predicted, ACD/Labs)(ph=7)-3.27
  • LogSw (predicted, AB/LogsW2.0)0.01
  • Sw (mg/ml) (predicted, ACD/Labs)0.01
  • No.of HBond Donors2
  • No.of HBond Acceptors3
  • No.of Rotatable Bonds9
  • TPSA43.7
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyAn antihistamine formerly used for the treatment of allergic conditions.
  • Absorption_value100.0
  • Absorption (description)On the basis of a mass balance study using 14C labeled terfenadine the oral absorption of terfenadine was estimated to be at least 70%
  • Caco_2N/A
  • Bioavailability1.0
  • Protein binding97.0
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmHepatic
  • Half life3.5 h
  • ExcretionN/A
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityMild (e.g., headache, nausea, confusion), but adverse cardiac events including cardiac arrest, ventricular arrhythmias including torsades de pointes and QT prolongation have been reported. LD50=mg/kg (orally in mice)
  • LD50 (rat)N/A
  • LD50 (mouse)N/A