- Molecular NameDicloxacillin
- SynonymDiclossacillina [DCIT]; Dicloxacilin; Dicloxacilina [INN-Spanish]; Dicloxacillin Sodium; Dicloxacilline [INN-French]; Dicloxacillinum [INN-Latin]; Dicloxacycline
- Weight470.333
- Drugbank_IDDB00485
- ACS_NO3116-76-5
- Show 3D model
- LogP (experiment)2.91
- LogP (predicted, AB/LogP v2.0)3.12
- pka2.8
- LogD (pH=7, predicted)-0.84
- Solubility (experiment)0.00363 mg/ml
- LogS (predicted, ACD/Labs)(ph=7)-1.39
- LogSw (predicted, AB/LogsW2.0)0.07
- Sw (mg/ml) (predicted, ACD/Labs)0.09
- No.of HBond Donors2
- No.of HBond Acceptors8
- No.of Rotatable Bonds4
- TPSA138.04
- StatusFDA approved
- AdministrationN/A
- PharmacologyA narrow spectrum beta-lactam antibiotic of the penicillin class. It is used to treat infections caused by susceptible Gram-positive bacteria. Notably, it is active against beta-lactamase-producing organisms such as Staphylococcus aureus
- Absorption_valueN/A
- Absorption (description)Absorption of the isoxazolyl penicillins after oral administration is rapid but incomplete: peak blood levels are achieved in 1-1.5 hours. Oral absorption of cloxacillin, dicloxacillin, oxacillin and nafcillin is delayed when the drugs are administered after meals.
- Caco_2N/A
- Bioavailability67.5
- Protein binding95.8
- Volume of distribution (VD)0.086 L/kg
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmHepatic
- Half life0.7 h
- ExcretionRenal and biliary
- Urinary Excretion60
- Clerance1.6 ml/min/kg
- ToxicityN/A
- LD50 (rat) 3579 mg/kg
- LD50 (mouse)N/A