- Molecular NameFlucloxacillin
- SynonymFloxacillin; Flucloxacilina [INN-Spanish]; Flucloxacillin Sodium; Flucloxacillin-Sodium; Flucloxacilline [INN-French]; Flucloxacillinum [INN-Latin]
- Weight467.905
- Drugbank_IDDB00301
- ACS_NO5250-39-5
- Show 3D model
- LogP (experiment)2.61
- LogP (predicted, AB/LogP v2.0)2.7
- pka2.7
- LogD (pH=7, predicted)-1.26
- Solubility (experiment)Freely soluble in water
- LogS (predicted, ACD/Labs)(ph=7)-0.99
- LogSw (predicted, AB/LogsW2.0)0.11
- Sw (mg/ml) (predicted, ACD/Labs)0.15
- No.of HBond Donors2
- No.of HBond Acceptors8
- No.of Rotatable Bonds4
- TPSA138.04
- StatusFDA approved
- AdministrationOral, IM, IV, intrapleural, intraarticular
- PharmacologyA narrow spectrum beta-lactam antibiotic of the penicillin class. It is used to treat infections caused by susceptible Gram-positive bacteria.
- Absorption_value80.0
- Absorption (description)Absorption: Flucloxacillin is stable in acid media and can therefore be administered either by the oral or parenteral route.
- Caco_2N/A
- Bioavailability60.0
- Protein binding95.0
- Volume of distribution (VD)N/A
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmHepatic; In normal subjects approximately 10% of the flucloxacillin administered is metabolized to penicilloic acid.
- Half life0.75~1 h
- ExcretionRenal
- Urinary ExcretionN/A
- CleranceN/A
- ToxicityRash, itching, diarrhoea, allergic reactions, colitis, jaundice, nausea and vomiting.
- LD50 (rat)N/A
- LD50 (mouse)N/A