- Molecular NameCefixime
- SynonymCefixim; Cefixima [Spanish]; Cefixime Anhydrous; Cefiximum [Latin]
- Weight465.467
- Drugbank_IDDB00671
- ACS_NO79350-37-1
- Show 3D model
- LogP (experiment)-0.559
- LogP (predicted, AB/LogP v2.0)-0.93
- pkaN/A
- LogD (pH=7, predicted)-5.8
- Solubility (experiment)0.05511 mg/ml
- LogS (predicted, ACD/Labs)(ph=7)0.33
- LogSw (predicted, AB/LogsW2.0)2.64
- Sw (mg/ml) (predicted, ACD/Labs)1.95
- No.of HBond Donors5
- No.of HBond Acceptors12
- No.of Rotatable Bonds8
- TPSA245.89
- StatusFDA approved
- AdministrationN/A
- PharmacologyAn oral third generation cephalosporin antibiotic. It is used to treat gonorrhea,tonsilitis,and pharyngitis.
- Absorption_value60.0
- Absorption (description)40 to 50% of an orally administered dose of cefixime (tablet form or as a suspension) is slowly absorbed.
- Caco_2N/A
- Bioavailability47.0
- Protein binding67.0
- Volume of distribution (VD)0.30 L/kg
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmThere is no evidence of metabolism. Cefixime crosses the placenta.
- Half life3.0~4.0 h
- Excretion20% of a dose (or 50% of the absorbed dose) is excreted unchanged in the urine within 24 h. Possibly up to 60% is eliminated by non-renal pathways, with some excretion in faeces as bile.
- Urinary Excretion41
- Clerance1.3 ml/min/kg
- ToxicityDiarrhoea and pseudomembranous colitis can be mild to life-threatening. Doses up to 2 g have been administered and no other serious toxic effects observed.
- LD50 (rat)N/A
- LD50 (mouse)N/A