- Molecular NameLacidipine
- SynonymNA
- Weight455.551
- Drugbank_IDN/A
- ACS_NO103890-78-4
- Show 2D model
- LogP (experiment)5.2
- LogP (predicted, AB/LogP v2.0)5.53
- pkaN/A
- LogD (pH=7, predicted)5.53
- Solubility (experiment)0.0000352 mg/ml
- LogS (predicted, ACD/Labs)(ph=7)-5.67
- LogSw (predicted, AB/LogsW2.0)0.0
- Sw (mg/ml) (predicted, ACD/Labs)0.0
- No.of HBond Donors1
- No.of HBond Acceptors7
- No.of Rotatable Bonds11
- TPSA90.93
- StatusN/A
- AdministrationN/A
- PharmacologyA calcium channel blocker.
- Absorption_value98.0
- Absorption (description)Lacidipine is rapidly but poorly absorbed after oral administration
- Caco_2N/A
- Bioavailability18.0
- Protein binding95.0
- Volume of distribution (VD)0.9 to 2.3 L/kg also reported as 537 L with high inter-subject variation.
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmUndergoes extensive first-pass metabolism. Two main metabolites have been identified as a pyridine analogue and a carboxylic acid analogue. It is eliminated by metabolism in the liver and the metabolites are excreted mainly via bile.
- Half life13~19 h
- ExcretionApprox. 70% of an oral dose is eliminated in faeces and the remainder in urine. No parent drug has been detected in urine or faeces.
- Urinary ExcretionN/A
- CleranceN/A
- ToxicityN/A
- LD50 (rat)N/A
- LD50 (mouse)N/A