• Molecular NameFluocinolone Acetonide
  • Synonymflucinolone; Fluocinolonacetonidum; Fluocinolone acetonide [DCIT]; Fluocinoloni acetonidum [INN-Latin]
  • Weight452.494
  • Drugbank_IDDB00591
  • ACS_NO67-73-2
  • Show 2D model
  • LogP (experiment)2.5
  • LogP (predicted, AB/LogP v2.0)2.48
  • pka2.698
  • LogD (pH=7, predicted)2.48
  • Solubility (experiment)0.011 mg/ml
  • LogS (predicted, ACD/Labs)(ph=7)-3.82
  • LogSw (predicted, AB/LogsW2.0)0.05
  • Sw (mg/ml) (predicted, ACD/Labs)0.07
  • No.of HBond Donors2
  • No.of HBond Acceptors6
  • No.of Rotatable Bonds2
  • TPSA93.06
  • StatusFDA approved
  • AdministrationTopical
  • PharmacologyA corticosteroid primarily used in dermatology to reduce skin inflammation and relieve itching.
  • Absorption_valueN/A
  • Absorption (description)Rapidly absorbed (15 minutes)
  • Caco_2N/A
  • BioavailabilityN/A
  • Protein bindingN/A
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmHepatic, CYP3A4-mediated
  • Half life1.5 h
  • ExcretionN/A
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityAdverse reactions associated with ocular administration of corticosteroids include elevated intraocular pressure with possible development of glaucoma, optic nerve damage, and visual acuity and field defects, posterior subcapsular cataract formation, delayed wound healing, and perforation of the globe where there is thinning of the sclera.
  • LD50 (rat)N/A
  • LD50 (mouse)N/A