• Molecular NameTetrahydrofolic acid
  • Synonym(6S)-tetrahydrofolate; 5,6,7,8-tetrahydrofolate; 5,6,7,8-tetrahydrofolic acid; FH4; folate-H4; H4PteGlu; N-(4-(((2-Amino-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)glutamic acid; tetra-H-folate; tetrahydrafolate; tetrahydrofolate; tetrahydropteroyl mono-L-glutamate; tetrahydropteroylglutamate; th-folate; THF
  • Weight445.436
  • Drugbank_IDDB00116
  • ACS_NO29347-89-5
  • Show 3D model
  • LogP (experiment)N/A
  • LogP (predicted, AB/LogP v2.0)-2.37
  • pkaN/A
  • LogD (pH=7, predicted)-7.05
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)0.35
  • LogSw (predicted, AB/LogsW2.0)0.05
  • Sw (mg/ml) (predicted, ACD/Labs)139.48
  • No.of HBond Donors9
  • No.of HBond Acceptors13
  • No.of Rotatable Bonds9
  • TPSA207.27
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyTetrahydrofolic acid is reduced by the drug methotrexate, which is used to impair nucleotide synthesis. This drug is a potent chemotherapy and anti rheumatic.
  • Absorption_valueN/A
  • Absorption (description)N/A
  • Caco_2N/A
  • BioavailabilityN/A
  • Protein bindingN/A
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmN/A
  • Half lifeN/A
  • ExcretionN/A
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityN/A
  • LD50 (rat)N/A
  • LD50 (mouse)N/A