• Molecular NameTetracycline
  • SynonymAnhydrotetracycline; TC; Tetracycline HCl
  • Weight444.44
  • Drugbank_IDDB00759
  • ACS_NO60-54-8
  • Show 3D model
  • LogP (experiment)-1.25
  • LogP (predicted, AB/LogP v2.0)-0.95
  • pka3.3
  • LogD (pH=7, predicted)-3.65
  • Solubility (experiment)0.337 mg/ml
  • LogS (predicted, ACD/Labs)(ph=7)-2.26
  • LogSw (predicted, AB/LogsW2.0)1.19
  • Sw (mg/ml) (predicted, ACD/Labs)0.69
  • No.of HBond Donors7
  • No.of HBond Acceptors10
  • No.of Rotatable Bonds2
  • TPSA181.62
  • StatusFDA approved
  • Administrationoral, topical (skin & eye), im, iv
  • PharmacologyA broad-spectrum polyketide antibiotic produced by the Streptomyces genus of Actinobacteria, indicated for use against many bacterial infections.
  • Absorption_value80.0
  • Absorption (description)Bioavailability is less than 40% when administered via intramuscular injection, 100% intravenously, and 60-80% orally (fasting adults). Food and/or milk reduce GI absorption of oral preparations of tetracycline by 50% or more.
  • Caco_2N/A
  • Bioavailability70.0
  • Protein binding65.0
  • Volume of distribution (VD)1.5 L/kg
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmNot metabolised
  • Half life10.6 h
  • ExcretionFecal and Renal
  • Urinary Excretion58
  • Clerance1.67 ml/min/kg
  • ToxicityN/A
  • LD50 (rat)N/A
  • LD50 (mouse)LD50=808 mg/kg