• Molecular NameThiothixene
  • Synonym(e)-thiothixene; Cis-thiothixene; Thiothixine; Tiotixene; Tiotixeno [inn-spanish]; Tiotixenum [inn-latin]
  • Weight443.636
  • Drugbank_IDDB01623
  • ACS_NO5591-45-7
  • Show 2D model
  • LogP (experiment)3.78
  • LogP (predicted, AB/LogP v2.0)3.78
  • pka7.97
  • LogD (pH=7, predicted)2.68
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)-4.45
  • LogSw (predicted, AB/LogsW2.0)0.0
  • Sw (mg/ml) (predicted, ACD/Labs)0.0
  • No.of HBond Donors0
  • No.of HBond Acceptors5
  • No.of Rotatable Bonds5
  • TPSA77.54
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyA thioxanthene drug used as a typical antipsychotic medication.
  • Absorption_valueN/A
  • Absorption (description)N/A
  • Caco_2N/A
  • BioavailabilityN/A
  • Protein binding95.0
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmThiothixene is extensively metabolized in the liver.
  • Half life10~20 h
  • ExcretionN/A
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicitySymptoms of overdose include central nervous system depression, coma, difficulty swallowing, dizziness, drowsiness, head tilted to the side, low blood pressure, muscle twitching, rigid muscles, salivation, tremors, walking disturbances, and weakness.
  • LD50 (rat)LD50=100 (intraperitoneal)
  • LD50 (mouse)N/A