- Molecular NameDeflazacort
- SynonymNA
- Weight441.524
- Drugbank_IDN/A
- ACS_NO14484-47-0
- Show 2D model
- LogP (experiment)N/A
- LogP (predicted, AB/LogP v2.0)3.05
- pkaN/A
- LogD (pH=7, predicted)3.05
- Solubility (experiment)N/A
- LogS (predicted, ACD/Labs)(ph=7)-4.12
- LogSw (predicted, AB/LogsW2.0)0.01
- Sw (mg/ml) (predicted, ACD/Labs)0.03
- No.of HBond Donors1
- No.of HBond Acceptors7
- No.of Rotatable Bonds4
- TPSA102.26
- StatusN/A
- AdministrationN/A
- PharmacologyA glucocorticoid used as an anti-inflammatory and immunosuppressant.
- Absorption_valueN/A
- Absorption (description)Deflazacort is well absorbed from the gastro-intestinal tract
- Caco_2N/A
- Bioavailability68.0
- Protein binding40.0
- Volume of distribution (VD)Deflazacort-6-beta-hydroxide, 83 L.
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmImmediately converted by plasma esterases to its active metabolite, 21-desacetyldeflazacort with further metabolism to deflazacort-6-β-hydroxide.
- Half life2.1 h
- ExcretionElimination is mainly via the kidneys, with 70% of the administrated dose recovered in the urine and the remaining 30% in faeces.
- Urinary ExcretionN/A
- Clerance83.9 ± 24.5 (36 mg dose) to 97.1 ± 47.7 L/h (3 mg dose).
- ToxicityN/A
- LD50 (rat)N/A
- LD50 (mouse)N/A