• Molecular NameSertindole
  • SynonymSertindol [inn-spanish]; Sertindolum [inn-latin]
  • Weight440.95
  • Drugbank_IDDB06144
  • ACS_NO106516-24-9
  • Show 2D model
  • LogP (experiment)N/A
  • LogP (predicted, AB/LogP v2.0)4.51
  • pka8.9
  • LogD (pH=7, predicted)3.07
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)-4.64
  • LogSw (predicted, AB/LogsW2.0)0.02
  • Sw (mg/ml) (predicted, ACD/Labs)0.0
  • No.of HBond Donors1
  • No.of HBond Acceptors5
  • No.of Rotatable Bonds5
  • TPSA39.99
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyOne of the newer antipsychotic medications available.
  • Absorption_valueN/A
  • Absorption (description)Orally available.
  • Caco_2N/A
  • Bioavailability74.0
  • Protein binding99.5
  • Volume of distribution (VD)1887 to 2447 L (single doses of 4 and 8 mg); 809 L (multiple dosing 20 mg)
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmHepatic. Sertindole is metabolized by cytochrome P450 isoenzymes CYP 2D6 and CYP 3A4.
  • Half life3 days
  • ExcretionN/A
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityN/A
  • LD50 (rat)N/A
  • LD50 (mouse)N/A