• Molecular NameDomperidone
  • SynonymNA
  • Weight440.935
  • Drugbank_IDDB01184
  • ACS_NO57808-66-9
  • Show 2D model
  • LogP (experiment)4.05
  • LogP (predicted, AB/LogP v2.0)3.52
  • pka7.9
  • LogD (pH=7, predicted)2.14
  • Solubility (experiment)0.0199 mg/ml
  • LogS (predicted, ACD/Labs)(ph=7)-3.62
  • LogSw (predicted, AB/LogsW2.0)0.03
  • Sw (mg/ml) (predicted, ACD/Labs)0.0
  • No.of HBond Donors3
  • No.of HBond Acceptors8
  • No.of Rotatable Bonds6
  • TPSA79.95
  • StatusFDA approved
  • AdministrationOral, intravenous, rectal
  • PharmacologyAn antidopaminergic drug, developed by Janssen Pharmaceutica, and used orally, rectally or intravenously, generally to suppress nausea and vomiting. It has also been used to stimulate lactation.
  • Absorption_value95.0
  • Absorption (description)N/A
  • Caco_2N/A
  • Bioavailability15.0
  • Protein binding92.0
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmHepatic and intestinal (first-pass)
  • Half life7 h
  • ExcretionBreast milk, renal
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityN/A
  • LD50 (rat)N/A
  • LD50 (mouse)N/A