• Molecular NameCloxacillin
  • SynonymCloxacillin Sodium
  • Weight435.888
  • Drugbank_IDDB01147
  • ACS_NO61-72-3
  • Show 2D model
  • LogP (experiment)2.43
  • LogP (predicted, AB/LogP v2.0)2.51
  • pka2.78
  • LogD (pH=7, predicted)-1.45
  • Solubility (experiment)0.0139 mg/ml
  • LogS (predicted, ACD/Labs)(ph=7)-0.72
  • LogSw (predicted, AB/LogsW2.0)0.17
  • Sw (mg/ml) (predicted, ACD/Labs)0.2
  • No.of HBond Donors2
  • No.of HBond Acceptors8
  • No.of Rotatable Bonds4
  • TPSA138.04
  • StatusFDA approved
  • AdministrationOral, IM
  • PharmacologyA semisynthetic antibiotic in the same class as penicillin.
  • Absorption_valueN/A
  • Absorption (description)Incompletely absorbed after oral administration.
  • Caco_2N/A
  • Bioavailability40.0
  • Protein binding95.0
  • Volume of distribution (VD)0.1 L/kg
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmN/A
  • Half life0.5~1.5 h
  • ExcretionAbout 35% of an oral dose is excreted in the urine unchanged in 12 h, together with about 11% as penicilloic acid; about 10% of a dose is excreted in the bile.
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicitySymptoms of overdose include wheezing, tightness in the chest, fever, itching, bad cough, blue skin color, fits, and swelling of face, lips, tongue, or throat.
  • LD50 (rat)5000 mg/kg; Intravenous LD50 in rat is 1660 mg/kg
  • LD50 (mouse)5000 mg/kg