• Molecular NameFlupenthixol
  • SynonymFlupenthixole
  • Weight434.526
  • Drugbank_IDDB00875
  • ACS_NO2709-56-0
  • Show 3D model
  • LogP (experiment)4.694
  • LogP (predicted, AB/LogP v2.0)4.58
  • pkaN/A
  • LogD (pH=7, predicted)3.79
  • Solubility (experiment)0.000346 mg/ml
  • LogS (predicted, ACD/Labs)(ph=7)-3.24
  • LogSw (predicted, AB/LogsW2.0)0.01
  • Sw (mg/ml) (predicted, ACD/Labs)0.09
  • No.of HBond Donors1
  • No.of HBond Acceptors3
  • No.of Rotatable Bonds6
  • TPSA52.01
  • StatusFDA approved
  • AdministrationIntramuscular, Oral
  • PharmacologyA typical antipsychotic drug.
  • Absorption_value100.0
  • Absorption (description)N/A
  • Caco_2N/A
  • Bioavailability50.0
  • Protein binding99.0
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmMainly hepatic
  • Half lifeBiological half-life of flupentixol hydrochloride, about 35 h.
  • ExcretionN/A
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityN/A
  • LD50 (rat) LD50=791 mg/kg, LD50=37 mg/kg (IV in rats)
  • LD50 (mouse)LD50=300 mk/kg, LD50=87 mk/kg (IV in mice);