• Molecular NameBenzthiazide
  • SynonymNA
  • Weight431.945
  • Drugbank_IDDB00562
  • ACS_NO91-33-8
  • Show 3D model
  • LogP (experiment)1.73
  • LogP (predicted, AB/LogP v2.0)2.47
  • pka6.0
  • LogD (pH=7, predicted)2.47
  • Solubility (experiment)0.00891 mg/ml
  • LogS (predicted, ACD/Labs)(ph=7)-4.58
  • LogSw (predicted, AB/LogsW2.0)0.0
  • Sw (mg/ml) (predicted, ACD/Labs)0.01
  • No.of HBond Donors2
  • No.of HBond Acceptors7
  • No.of Rotatable Bonds5
  • TPSA151.96
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyA thiazide diuretic used in the treatment of high blood pressure and edema.
  • Absorption_valueN/A
  • Absorption (description)Poorly absorbed after oral administration.
  • Caco_2N/A
  • Bioavailability25.0
  • Protein binding30.0
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmN/A
  • Half life10~15 h
  • ExcretionLess than 10% of a dose is excreted in the urine as unchanged drug in 48 h, and about 80% of a dose is eliminated in the faeces.
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicitySymptoms of overdose include nausea, vomiting, fatigue, urinary problems and drowsiness.
  • LD50 (rat)N/A
  • LD50 (mouse)N/A