- Molecular NamePravastatin
- SynonymPravastatin Sodium; Pravastatina [Spanish]; Pravastatine [French]; Pravastatinum [Latin]
- Weight424.534
- Drugbank_IDDB00175
- ACS_NO81093-37-0
- Show 3D model
- LogP (experiment)2.18
- LogP (predicted, AB/LogP v2.0)2.56
- pkaN/A
- LogD (pH=7, predicted)-0.09
- Solubility (experiment)2.464 mg/ml
- LogS (predicted, ACD/Labs)(ph=7)-0.61
- LogSw (predicted, AB/LogsW2.0)0.34
- Sw (mg/ml) (predicted, ACD/Labs)0.26
- No.of HBond Donors4
- No.of HBond Acceptors7
- No.of Rotatable Bonds11
- TPSA124.29
- StatusFDA approved
- AdministrationN/A
- PharmacologyA member of the drug class of statins, used for lowering cholesterol and preventing cardiovascular disease.
- Absorption_value34.0
- Absorption (description)N/A
- Caco_2N/A
- Bioavailability18.0
- Protein binding45.5
- Volume of distribution (VD)0.46 L/kg at steady state.
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmHepatic, there is a small amount of metabolism by P450 enzymes, but this effect is so minimal that inhibitory pharmacokinetic drug interactions have no real effect on its overall activity and elimination. An in vitro study which found moderate affinity for P450 2C9 (major), 2D6 and 3A4.
- Half life0.8 h (A longer t1/2 = 1.8 +/- 0.8 hour reported for oral dosing; probably rate-limited by absorption)
- ExcretionN/A
- Urinary Excretion47
- Clerance13.5 ml/min/kg
- ToxicityN/A
- LD50 (rat)N/A
- LD50 (mouse)N/A