- Molecular NameBenazepril
- SynonymBenazepril HCl; Benazepril Hydrochloride; Benazeprilum [Latin]
- Weight424.497
- Drugbank_IDDB00542
- ACS_NO86541-75-5
- Show 2D model
- LogP (experiment)3.5
- LogP (predicted, AB/LogP v2.0)2.03
- pka3.1; 5.3
- LogD (pH=7, predicted)-1.16
- Solubility (experiment)N/A
- LogS (predicted, ACD/Labs)(ph=7)-2.47
- LogSw (predicted, AB/LogsW2.0)0.32
- Sw (mg/ml) (predicted, ACD/Labs)0.01
- No.of HBond Donors2
- No.of HBond Acceptors7
- No.of Rotatable Bonds10
- TPSA95.94
- StatusFDA approved
- AdministrationN/A
- PharmacologyA medication used to treat high blood pressure (hypertension), congestive heart failure, and chronic renal failure.
- Absorption_value50.0
- Absorption (description)A minimum of 37% of an oral dose of benazepril is absorbed (fasting)
- Caco_2N/A
- Bioavailability37.0
- Protein binding97.0
- Volume of distribution (VD)0.12 L/kg
- Blood/Plasma Partitioning ratio (D_blood)Benazeprilat is not extensively distributed into extravascular sites with minimum passage across the blood/brain barrier.
- MetabollsmHepatic glucuronidation. Rapidly converted to its active carboxylic metabolite, benazeprilat by enzymatic hydrolysis in the liver.
- Half life0.5~1.0 h
- ExcretionBenazepril is cleared mainly by metabolic transformation with <1% being excreted unchanged in urine along with its acyl glucuronide metabolite. Approximately 18% of an oral dose is recovered in urine as the diacid, benazeprilat. Peak plasma concentrations of benazeprilat occur 1 to 2 h after administration, if fasting, and 2 to 4 h in the non-fasting state. 11 to 12% of benazeprilat is excreted in bile and the majority in urine. Elimination is slow with renal impairment. Very small amounts of benazepril and benazeprilat are secreted into breast milk.
- Urinary Excretion<1
- Clerance0.35 ml/min/kg
- ToxicitySevere hypotension with acute overdose.
- LD50 (rat)N/A
- LD50 (mouse)N/A