- Molecular NameGallamine Triethiodide
- SynonymBenzcurine Iodide; Benzkurin; Gallamin; Gallamin Triethiodide; Gallamine; Gallamine Iodide; Gallamine Triethiiodide; Gallamine Triiodoethylate; Gallamone Triethiodide; Gallamonum; Triiodoethylate de Gallamine
- Weight423.642
- Drugbank_IDDB00483
- ACS_NO153-76-4
- Show 3D model
- LogP (experiment)N/A
- LogP (predicted, AB/LogP v2.0)3.47
- pkaN/A
- LogD (pH=7, predicted)-1.85
- Solubility (experiment)N/A
- LogS (predicted, ACD/Labs)(ph=7)0.37
- LogSw (predicted, AB/LogsW2.0)3.32
- Sw (mg/ml) (predicted, ACD/Labs)1.01
- No.of HBond Donors0
- No.of HBond Acceptors6
- No.of Rotatable Bonds18
- TPSA37.41
- StatusFDA approved
- AdministrationN/A
- PharmacologyA non-depolarising muscle relaxant also known under the trade name Flaxedil. It acts by combining with the cholinergic receptor sites in muscle and competitively blocking the transmitter action of acetylcholine. Gallamine has a parasympatholytic effect on the cardiac vagus nerve which causes tachycardia and occasionally hypertension.
- Absorption_valueN/A
- Absorption (description)Slowly and incompletely absorbed after oral administration; absorbed after IM administration but is generally given by the IV route.
- Caco_2N/A
- BioavailabilityN/A
- Protein bindingN/A
- Volume of distribution (VD)0.3 L/kg
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmN/A
- Half life2~3 h; greatly increased in renal failure.
- ExcretionAlmost 100% of a dose is excreted unchanged in the urine in 24 to 30 h. Negligible amounts are excreted in the bile.
- Urinary ExcretionN/A
- ClerancePlasma clearance, about 1.4 mL/min/kg.
- ToxicityN/A
- LD50 (rat)N/A
- LD50 (mouse)N/A