• Molecular NameTianeptine
  • SynonymStablon; Coaxil; Tatinol
  • Weight422.933
  • Drugbank_IDN/A
  • ACS_NO66981-73-5
  • Show 3D model
  • LogP (experiment)N/A
  • LogP (predicted, AB/LogP v2.0)3.76
  • pkaN/A
  • LogD (pH=7, predicted)1.66
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)-2.33
  • LogSw (predicted, AB/LogsW2.0)0.0
  • Sw (mg/ml) (predicted, ACD/Labs)0.02
  • No.of HBond Donors1
  • No.of HBond Acceptors6
  • No.of Rotatable Bonds7
  • TPSA86.3
  • StatusN/A
  • AdministrationN/A
  • PharmacologyA selective serotonin reuptake enhancer (SSRE) drug used for treating Major depressive episodes (mild, moderate, or severe).
  • Absorption_value99.0
  • Absorption (description)N/A
  • Caco_2N/A
  • Bioavailability99.0
  • Protein binding95.0
  • Volume of distribution (VD)0.5~0.8 L/kg; elderly, 0.41 L/kg
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmHepatic
  • Half life2.5 h; increased in patients with renal failure; prolonged in patients suffering from depression (6.3 h).
  • ExcretionRenal
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityN/A
  • LD50 (rat)N/A
  • LD50 (mouse)N/A