• Molecular NameDoripenem
  • SynonymNA
  • Weight420.511
  • Drugbank_IDDB06211
  • ACS_NO148016-81-3
  • Show 2D model
  • LogP (experiment)N/A
  • LogP (predicted, AB/LogP v2.0)-0.82
  • pkaN/A
  • LogD (pH=7, predicted)-3.34
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)-0.74
  • LogSw (predicted, AB/LogsW2.0)20.31
  • Sw (mg/ml) (predicted, ACD/Labs)76.11
  • No.of HBond Donors6
  • No.of HBond Acceptors10
  • No.of Rotatable Bonds7
  • TPSA195.74
  • StatusFDA approved
  • AdministrationIM, IV
  • PharmacologyAn ultra-broad spectrum injectable antibiotic.
  • Absorption_valueN/A
  • Absorption (description)N/A
  • Caco_2N/A
  • BioavailabilityN/A
  • Protein binding8.1
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmMetabolism of doripenem to a microbiologically inactive ring-opened metabolite (doripenem-M1) occurs primarily via dehydropeptidase-I. The mean (SD) plasma doripenem-M1-to-doripenem AUC ratio following single 500 mg and 1 g doses in healthy subjects is 18% (7.2%). In pooled human liver microsomes, no in vitro metabolism of doripenem could be detected, indicating that doripenem is not a substrate for hepatic CYP450 enzymes.
  • Half life1 h
  • ExcretionN/A
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityN/A
  • LD50 (rat)N/A
  • LD50 (mouse)N/A